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Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment

Makkar, Steve; Lipnicki, Darren; Crawford, John; Kochan, Nicole A; Castro-Costa, Erico; Lima-Costa, Maria Fernanda; Satler Diniz, Breno; Brayne, Carol; Stephan, Blossom CM; Llibre-Rodriguez, Juan J.; Anstey, Kaarin; Cherbuin, Nicolas

Description

Background: We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4). Methods: Participants were 30,785 dementia-free individuals aged 55-103 years, from 18 longitudinal cohort studies, with an average follow-up ranging between 2 and 10 years. Pooled hazard ratios were obtained from multilevel parametric survival analyses...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
URI: http://hdl.handle.net/1885/269911
Source: Archives of Gerontology and Geriatrics
DOI: 10.1016/j.archger.2020.104112

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