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High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A pi-stacking interactions for small-molecule recognition

Ou, Arnold; Schmidberger, Jason; Wilson, Katie; Evans, Cameron; Hargreaves, Jessica A.; Grigg, Melanie; O'Mara, Megan; Swaminathan Iyer, K.; Bond, Charles S.; Smith, Nicole M.


Aberrant KRAS signaling is a driver of many cancers and yet remains an elusive target for drug therapy. The nuclease hypersensitive element of the KRAS promoter has been reported to form secondary DNA structures called G-quadruplexes (G4s) which may play important roles in regulating KRAS expression, and has spurred interest in structural elucidation studies of the KRAS G-quadruplexes. Here, we report the first high-resolution crystal structure (1.6 A) of a KRAS G-quadruplex as a...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Nucleic Acids Research
DOI: 10.1093/nar/gkaa262
Access Rights: Open Access


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