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PPAR-delta Agonist MBX-8025 Abolishes Lipotoxicity andReverses NASH in Diabetic Obese Mice

Haczeyni, Fahrettin; Wang, Hans; Barn, Vanessa; Mridha, Auvro; Yeh, Matthew; Haigh, W Geoffrey; Ioannou, George; Choi, Yun Jung; McWerther, Charles; Teoh, Narcissus; Farrell, Geoffrey

Description

Background: Lipotoxicity associated with insulin resistance and diabetes is central to the pathogenesis of non-alcoholic steatohepatitis (NASH), and resultant liver fibrosis and cirrhosis. To date, only weight loss, which improves insulin sensitivity, reverses NASH fibrosis; pharmacological agents have limited efficacy. The mixed peroxisome proliferator-activated receptor-alpha/delta (PPAR-α/δ) agonist, GFT505, has demonstrated some efficacy in NASH. MBX-8025 is a selective PPAR-δ...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Conference paper
URI: http://hdl.handle.net/1885/267225
Source: Hepatology

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