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G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation

Murat, Pierre; Zhong, Jie; Lekieffre, Lea; Cowieson, Nathan P; Clancy, Jennifer; Preiss, Thomas; Balasubramanian, Shankar; Khanna, Rajiv; Tellam, Judy

Description

Viruses that establish latent infections have evolved unique mechanisms to avoid host immune recognition. Maintenance proteins of these viruses regulate their synthesis to levels sufficient for maintaining persistent infection but below threshold levels for host immune detection. The mechanisms governing this finely tuned regulation of viral latency are unknown. Here we show that mRNAs encoding gammaherpesviral maintenance proteins contain within their open reading frames clusters of unusual...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/26341
Source: Nature Chemical Biology
DOI: 10.1038/nchembio.1479

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