Mucosal HIV-1 Pox Virus Prime-Boost Immunization Induces High-Avidity CD8 + T Cells with Regime-Dependent Cytokine/Granzyme B Profiles
Date
2007
Authors
Turner, Stephen
McArthur, Craig
Sutherland, Duncan
Kim, Jee-Hye
Doherty, Peter
Ramshaw, Ian
Ranasinghe, Charani
Journal Title
Journal ISSN
Volume Title
Publisher
American Association of Immunologists
Abstract
The quality of virus-specific CD8+ CTL immune responses generated by mucosal and systemic poxvinis prime-boost vaccines were evaluated in terms of T cell avidity and single-cell analysis of effector gene expression. Intranasal (I.N.) immunization regimes
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Keywords
Keywords: cytokine; granzyme B; interleukin 4; live vaccine; messenger RNA; virus vector; adolescent; amino acid sequence; animal cell; animal experiment; article; CD8+ T lymphocyte; controlled study; cytokine production; cytotoxic T lymphocyte; female; gene expres
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Source
Journal of Immunology
Type
Journal article
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2037-12-31
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