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How does the gut microbiome influence immune checkpoint blockade therapy?

Almonte, Andrew; Rangarajan, Hareesha; Yip, Desmond; Fahrer, Aude

Description

Immune checkpoint blockade (ICB) therapies are revolutionary cancer treatments; however, they only benefit about a third of patients. Therefore, extensive research is underway to find methods to improve their therapeutic efficacy. One avenue of study that has recently emerged is to consider the role the gut microbiome plays in therapeutic success. Several high-impact studies have repeatedly shown that the presence, composition and level of diversity of the gut flora directly impact cancer...[Show more]

CollectionsANU Research Publications
Date published: 2020-11-22
Type: Journal article
URI: http://hdl.handle.net/1885/259081
Source: Immunology and Cell Biology
DOI: 10.1111/imcb.12423

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