Skip navigation
Skip navigation

How does the gut microbiome influence immune checkpoint blockade therapy?

Almonte, Andrew; Rangarajan, Hareesha; Yip, Desmond; Fahrer, Aude

Description

Immune checkpoint blockade (ICB) therapies are revolutionary cancer treatments; however, they only benefit about a third of patients. Therefore, extensive research is underway to find methods to improve their therapeutic efficacy. One avenue of study that has recently emerged is to consider the role the gut microbiome plays in therapeutic success. Several high-impact studies have repeatedly shown that the presence, composition and level of diversity of the gut flora directly impact cancer...[Show more]

dc.contributor.authorAlmonte, Andrew
dc.contributor.authorRangarajan, Hareesha
dc.contributor.authorYip, Desmond
dc.contributor.authorFahrer, Aude
dc.date.accessioned2022-02-06T22:57:21Z
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/259081
dc.description.abstractImmune checkpoint blockade (ICB) therapies are revolutionary cancer treatments; however, they only benefit about a third of patients. Therefore, extensive research is underway to find methods to improve their therapeutic efficacy. One avenue of study that has recently emerged is to consider the role the gut microbiome plays in therapeutic success. Several high-impact studies have repeatedly shown that the presence, composition and level of diversity of the gut flora directly impact cancer treatment outcome in both mice and patients. These studies have also highlighted the danger of using antibiotics shortly before or during cancer treatments. However, there are still several questions that need to be answered, including which bacteria promote the greatest benefit, the mechanisms by which they act and how we can use this information to influence treatment outcome. In this review, we explain how the gut microbiome was realized to be of such importance and propose hypotheses for why gut flora have such a critical impact on ICB therapeutic success. We also describe a hypothetical mechanism involving bacterial translocation out of the gut and into the tumor, whereby the bacteria act in an adjuvant capacity to facilitate an antitumor response. By highlighting key papers in the field, we hope to hasten research on the subject so as to find a means to improve the therapeutic efficacy of these ground-breaking cancer treatments.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherBlackwell Publishing Ltd
dc.rights© 2020 Australian and New Zealand Society for Immunology, Inc.
dc.sourceImmunology and Cell Biology
dc.subjectCTLA-4/PD-1/PD-L1
dc.subjectgut microbiome
dc.subjectimmune checkpoint blockade
dc.subjectimmunology
dc.subjectimmunotherapy
dc.subjectlymphocytes
dc.subjectT cells
dc.subjecttumor immunology
dc.titleHow does the gut microbiome influence immune checkpoint blockade therapy?
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume99
dcterms.dateAccepted2020-11-01
dc.date.issued2020-11-22
local.identifier.absfor110303 - Clinical Microbiology
local.identifier.absfor110709 - Tumour Immunology
local.identifier.absfor111204 - Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
local.identifier.ariespublicationu4008405xPUB178
local.publisher.urlhttps://onlinelibrary.wiley.com/
local.type.statusPublished Version
local.contributor.affiliationAlmonte, Andrew, College of Science, ANU
local.contributor.affiliationRangarajan, Hareesha, College of Science, ANU
local.contributor.affiliationYip, Desmond, College of Health and Medicine, ANU
local.contributor.affiliationFahrer, Aude, College of Science, ANU
local.description.embargo2099-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage361
local.bibliographicCitation.lastpage372
local.identifier.doi10.1111/imcb.12423
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
local.identifier.absseo920108 - Immune System and Allergy
local.identifier.absseo920102 - Cancer and Related Disorders
dc.date.updated2020-12-20T07:28:45Z
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Almonte_How_does_the_gut_microbiome_2020.pdf2.03 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator