Structural and genetic characterization of the Shigella boydii type 10 and type 6 O antigens
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Senchenkova, Sof'ya N; Feng, Lu; Yang, Jinghua; Shashkov, Alexander S; Cheng, Jiansong; Liu, Dan; Knirel, Yuriy; Reeves, Peter R; Jin, Qi; Ye, Qiang; Wang, Lei
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Comparison of the O antigens of Shigella boydii types 10 and 6 by chemical analysis and nuclear magnetic resonance spectroscopy showed that their structures are similar, with the only difference being the presence or absence of D-ribofuranose, which is the immunodominant sugar in S. boydii type 10. In S. boydii type 6, a residue previously reported as α-D-GlcpA, was shown to be β-D-GlcpA as in S. boydii type 10. S. boydii types 10 and 6 are reported not to cross-react serologically, and the...[Show more]
dc.contributor.author | Senchenkova, Sof'ya N | |
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dc.contributor.author | Feng, Lu | |
dc.contributor.author | Yang, Jinghua | |
dc.contributor.author | Shashkov, Alexander S | |
dc.contributor.author | Cheng, Jiansong | |
dc.contributor.author | Liu, Dan | |
dc.contributor.author | Knirel, Yuriy | |
dc.contributor.author | Reeves, Peter R | |
dc.contributor.author | Jin, Qi | |
dc.contributor.author | Ye, Qiang | |
dc.contributor.author | Wang, Lei | |
dc.date.accessioned | 2015-12-07T22:46:45Z | |
dc.identifier.issn | 0021-9193 | |
dc.identifier.uri | http://hdl.handle.net/1885/25906 | |
dc.description.abstract | Comparison of the O antigens of Shigella boydii types 10 and 6 by chemical analysis and nuclear magnetic resonance spectroscopy showed that their structures are similar, with the only difference being the presence or absence of D-ribofuranose, which is the immunodominant sugar in S. boydii type 10. In S. boydii type 6, a residue previously reported as α-D-GlcpA, was shown to be β-D-GlcpA as in S. boydii type 10. S. boydii types 10 and 6 are reported not to cross-react serologically, and the role of D-ribofuranose in the specificity of S. boydii was confirmed by making a mutant of type 10 that lacked D-ribofuranose. However, S. boydii type 11, which has a D-ribofuranose but with different linkage does show cross-reaction with type 10. The O-antigen gene loci of S. boydii types 10 and 6 were shown to be virtually identical except that orf8 (wbaM), which was confirmed as the ribofuranosyltransferase gene, is interrupted by IS629 in type 6. Therefore, it is proposed that the O-antigen gene cluster of S. boydii type 6 was derived from type 10 by an IS element insertion. | |
dc.publisher | American Society for Microbiology | |
dc.source | Journal of Bacteriology | |
dc.subject | Keywords: dextro ribofuranose; O antigen; ribofuranosyltransferase; sugar; transferase; unclassified drug; article; chemical analysis; cross reaction; gene cluster; gene identification; gene insertion; gene locus; gene structure; immunogenicity; linkage analysis; m | |
dc.title | Structural and genetic characterization of the Shigella boydii type 10 and type 6 O antigens | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 187 | |
dc.date.issued | 2005 | |
local.identifier.absfor | 030400 - MEDICINAL AND BIOMOLECULAR CHEMISTRY | |
local.identifier.ariespublication | u4222028xPUB41 | |
local.type.status | Published Version | |
local.contributor.affiliation | Senchenkova, Sof'ya N, Russian Academy of Sciences | |
local.contributor.affiliation | Feng, Lu, Nankai University | |
local.contributor.affiliation | Yang, Jinghua, Nankai University | |
local.contributor.affiliation | Shashkov, Alexander S, Russian Academy of Sciences | |
local.contributor.affiliation | Cheng, Jiansong, Nankai University | |
local.contributor.affiliation | Liu, Dan, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Knirel, Yuriy, Russian Academy of Sciences | |
local.contributor.affiliation | Reeves, Peter R, University of New South Wales | |
local.contributor.affiliation | Jin, Qi, State Key Laboratory for Molecular Virology | |
local.contributor.affiliation | Ye, Qiang, National Institute for the Control of Pharmaceutical and Biological Products | |
local.contributor.affiliation | Wang, Lei, Nankai University | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 7 | |
local.bibliographicCitation.startpage | 2551 | |
local.bibliographicCitation.lastpage | 2554 | |
local.identifier.doi | 10.1128/JB.187.7.2551-2554.2005 | |
dc.date.updated | 2015-12-07T11:45:15Z | |
local.identifier.scopusID | 2-s2.0-20144366308 | |
Collections | ANU Research Publications |
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