JMJ14, a JmjC domain protein,is required for RNA silencing and cell-to-cell movement of an RNA silencing signal in Arabidopsis
Date
2010
Authors
Searle, Iain
Pontes , Olga
Melnyk , Charles W
Smith , Lisa M
Baulcombe , David
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Cold Spring Harbor Laboratory Press
Abstract
JMJ14 is a histone H3 Lys4 (H3K4) trimethyl demethylase that affects mobile RNA silencing in an Arabidopsis transgene system. It also influences CHH DNA methylation, abundance of endogenous transposon transcripts, and flowering time. JMJ14 acts at a point in RNA silencing pathways that is downstream from RNA-dependent RNA polymerase 2 (RDR2) and Argonaute 4 (AGO4). Our results illustrate a link between RNA silencing and demethylation of histone H3 trimethylysine. We propose that JMJ14 acts downstream from the Argonaute effector complex to demethylate histone H3K4 at the target of RNA silencing.
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Keywords
Keywords: protein; protein argonaute 4; protein jmj14; RNA; RNA directed RNA polymerase; RNA directed RNA polymerase 2; unclassified drug; Arabidopsis; article; cell interaction; cell motion; gene silencing; nonhuman; plant genetics; priority journal; protein analy Arabidopsis; Chromatin; Histone demethylase; RNA silencing; siRNAs
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Genes and Development
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Journal article
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2037-12-31
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