Goonasekera, Sanjeewa A; Beard, Nicole; Groom, Linda; Kimura, Takashi; Lyfenko, Alla D; Rosenfeld, Andrew; Marty, Isabelle; Dulhunty, Angela; Dirksen, Robert
Ca2+ release from intracellular stores is controlled by complex interactions between multiple proteins. Triadin is a transmembrane glycoprotein of the junctional sarcoplasmic reticulum of striated muscle that interacts with both calsequestrin and the type 1 ryanodine receptor (RyR1) to communicate changes in luminal Ca2+ to the release machinery. However, the potential impact of the triadin association with RyR1 in skeletal muscle excitation-contraction coupling remains elusive. Here we show...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.