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Triadin Binding to the C-Terminal Luminal Loop of the Ryanodine Receptor is Important for Skeletal Muscle Excitation-Contraction Coupling

Goonasekera, Sanjeewa A; Beard, Nicole; Groom, Linda; Kimura, Takashi; Lyfenko, Alla D; Rosenfeld, Andrew; Marty, Isabelle; Dulhunty, Angela; Dirksen, Robert


Ca2+ release from intracellular stores is controlled by complex interactions between multiple proteins. Triadin is a transmembrane glycoprotein of the junctional sarcoplasmic reticulum of striated muscle that interacts with both calsequestrin and the type 1 ryanodine receptor (RyR1) to communicate changes in luminal Ca2+ to the release machinery. However, the potential impact of the triadin association with RyR1 in skeletal muscle excitation-contraction coupling remains elusive. Here we show...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of General Physiology
DOI: 10.1085/jgp.200709790


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