B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
Avery, Danielle T; Deenick, Elissa; Ma, Cindy; Suryani, Santi; Simpson, Nick; Chew, Gary; Chan, Tyani; Palendira, Umamainthan; Bustamante, Jacinta; Boisson-Dupuis, Stephanie; Choo, Sharon; Bleasel, Karl E.; Cook, Matthew; Arkwright, Peter D
Engagement of cytokine receptors by specific ligands activate Janus kinase-signal transducer and activator of transcription (STAT) signaling pathways. The exact roles of STATs in human lymphocyte behavior remain incompletely defined. Interleukin (IL)-21 activates STAT1 and STAT3 and has emerged as a potent regulator of B cell differentiation. We have studied patients with inactivating mutations in STAT1 or STAT3 to dissect their contribution to B cell function in vivo and in response to IL-21...[Show more]
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|Source:||Journal of Experimental Medicine|
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