Adaptive immunity to vaccinia virus: revisiting an old friend
Date
2007
Authors
Tscharke, David
Journal Title
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Volume Title
Publisher
Future Science Group
Abstract
The study of immunity to vaccinia virus has had a renaissance in recent years, largely owing to a desire to produce a safe and efficacious vaccine against smallpox in the context of biodefense concerns. This review focuses on three areas that have seen recent advances: the mapping of epitopes, data from the clinic (including efforts to determine the longevity of responses in humans and recent smallpox vaccine trials) and the use of animal models to determine the requisites for successful immunity and the effect of vaccinia virus immunomodulators on adaptive immune responses. This is intended to be a snapshot of areas generating current interest rather than a comprehensive review, and each area is discussed in terms of current achievements and challenges for the future.
Description
Keywords
Keywords: HLA A2 antigen; immunomodulating agent; interleukin 1beta; lc 16m8; modified vaccinia virus Ankara vaccine; neutralizing antibody; protein A41; serine proteinase inhibitor; smallpox vaccine; transcription factor T bet; unclassified drug; vaccinia antibody Adaptive immunity; Animal models; Clinical trial; Epitope mapping; Immune modulation; Smallpox vaccine; Vaccinia virus
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Source
Future Virology
Type
Journal article
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Restricted until
2037-12-31