Adaptive immunity to vaccinia virus: revisiting an old friend
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The study of immunity to vaccinia virus has had a renaissance in recent years, largely owing to a desire to produce a safe and efficacious vaccine against smallpox in the context of biodefense concerns. This review focuses on three areas that have seen recent advances: the mapping of epitopes, data from the clinic (including efforts to determine the longevity of responses in humans and recent smallpox vaccine trials) and the use of animal models to determine the requisites for successful...[Show more]
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