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Molecular Determinants for Substrate Interactions with the Glycine Transporter GlyT2

Carland, Jane E; Thomas, Michael; Mostyn, Shannon; Subramanian, Nandhitha; O'Mara, Megan; Ryan, Renae M.; Vandenberg, Robert J


Transporters in the SLC6 family play key roles in regulating neurotransmission and are the targets for a wide range of therapeutics. Important insights into the transport mechanisms and the specificity of drug interactions of SLC6 transporters have been obtained from the crystal structures of a bacterial homologue of the family, LeuTAa, and more recently the Drosophila dopamine transporter and the human serotonin transporter. However, there is disputed evidence that the bacterial leucine...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.7b00407


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