Skip navigation
Skip navigation

Molecular Determinants for Substrate Interactions with the Glycine Transporter GlyT2

Carland, Jane E; Thomas, Michael; Mostyn, Shannon; Subramanian, Nandhitha; O'Mara, Megan; Ryan, Renae M.; Vandenberg, Robert J

Description

Transporters in the SLC6 family play key roles in regulating neurotransmission and are the targets for a wide range of therapeutics. Important insights into the transport mechanisms and the specificity of drug interactions of SLC6 transporters have been obtained from the crystal structures of a bacterial homologue of the family, LeuTAa, and more recently the Drosophila dopamine transporter and the human serotonin transporter. However, there is disputed evidence that the bacterial leucine...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/243871
Source: ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.7b00407

Download

File Description SizeFormat Image
01_Carland_Molecular_Determinants_for_2017.pdf2.7 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator