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Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone

Sugui, Janyce; Pardo, Julian; Chang, Yun C.; Zarember, Kol A; Nardone, Glenn; Galvez, Eva; Mullbacher, Arno; Gallin, John I; Simon, Markus M; Kwon-Chung, June Kyung


Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence factor of Aspergillus fumigatus. Recent studies using mutants lacking gliotoxin production, however, suggested that the mycotoxin is not important for pathogenesis of A. fumigatus in neutropenic mice resulting from treatment with cyclophosphomide and hydrocortisone. In this study, we report on the pathobiological role of gliotoxin in two different mouse strains, 129/Sv and BALB/c, that were immunosuppressed...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Eukaryotic Cell
DOI: 10.1128/EC.00141-07


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