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Collateral sensitivity as a strategy against cancer multidrug resistance

Pluchino, Kristen M.; Hall, Matthew D.; Goldsborough, Andrew S.; Gottesman, Michael M.; Callaghan, Richard


While chemotherapy remains the most effective treatment for disseminated tumors, acquired or intrinsic drug resistance accounts for approximately 90% of treatment failure. Multidrug resistance (MDR), the simultaneous resistance to drugs that differ both structurally and mechanistically, often results from drug efflux pumps in the cell membrane that reduce intracellular drug levels to less than therapeutic concentrations. Expression of the MDR transporter P-glycoprotein (P-gp, MDR1, ABCB1) has...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Drug Resistance Updates
DOI: 10.1016/j.drup.2012.03.002


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