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Toward an improved understanding of the glutamate mutase system

Sandala, Gregory; Smith, David M; Marsh, E Neil G; Radom, Leo


High-level quantum chemistry calculations have been used to examine the catalytic reactions of adenosylcobalamin-dependent glutamate mutase (GM) with the natural substrate (S)-glutamic acid. We have also examined the rearrangement of (S)-2-hydroxyglutaric acid, (S)-2-thiolglutaric acid, and 2-ketoglutaric acid, all of which have previously been shown to react as substrates or inhibitors of the enzyme. Our calculations support the notion that the 100-fold difference in kcat between glutamate and...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja066432c


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