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Eotaxin Selectively Binds Heparin: An interaction that protects eotaxin from proteolysis and potentiates chemotactic activity in vivo

Ellyard, Julia; Simson, Ljubov; Bezos, Anna; Johnston, Kellie; Freeman, Craig; Parish, Christopher

Description

An important feature of chemokines is their ability to bind to the glycosaminoglycan (GAG) side chains of proteoglycans, predominately heparin and heparan sulfate. To date, all chemokines tested bind to immobilized heparin in vitro, as well as cell surface heparan sulfate in vitro and in vivo. These interactions play an important role in modulating the action of chemokines by facilitating the formation of stable chemokine gradients within the vascular endothelium and directing leukocyte...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/23769
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M608046200

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