Targeting Nutrient Uptake Mechanisms in Plasmodium
The proliferation of the intraerythrocytic malaria parasite is dependent on the uptake from the blood plasma, and from the cytoplasm of the host cell, of a range of essential nutrients. These compounds are taken up into the parasitised cell via a combination of constitutively active endogenous host cell transporters and new parasite-induced permeability pathways. On entering the infected cell they are taken up by the intracellular parasite, across the parasitophorous vacuole and parasite plasma...[Show more]
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|Source:||Current Drug Targets|
|01_Kirk_Targeting_Nutrient_Uptake_2007.pdf||528.63 kB||Adobe PDF||Request a copy|
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