Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?
Date
2014
Authors
Luk, F
Bebawy, Mary
Callaghan, Richard
Journal Title
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Volume Title
Publisher
American Society for Pharmacology and Experimental Therapeutics
Abstract
P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous
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Source
Drug Metabolism and Disposition
Type
Journal article
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Restricted until
2037-12-31