Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?
P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous
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|Source:||Drug Metabolism and Disposition|
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