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Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?

Callaghan, Richard; Luk, F; Bebawy, Mary

Description

P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/23663
Source: Drug Metabolism and Disposition
DOI: 10.1124/dmd.113.056176

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