Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design
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Chitty, Jessica L; Blake, Kirsten L; Blundell, Ross D; Koh, Y. Q. Andre E; Thompson, Merinda; Robertson, Avril; Butler, Mark S; Cooper, Matthew A.; Kappler, Ulrike; Williams, Simon; Kobe, Bostjan; Fraser, James A
Description
There is significant clinical need for new antifungal agents to manage infections with pathogenic species such as Cryptococcus neoformans. Because the purine biosynthesis pathway is essential for many metabolic processes, such as synthesis of DNA and RNA and energy generation, it may represent a potential target for developing new antifungals. Within this pathway, the bifunctional enzyme adenylosuccinate (ADS) lyase plays a role in the formation of the key intermediates inosine monophosphate...[Show more]
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/236327 |
Source: | Journal of Biological Chemistry |
DOI: | 10.1074/jbc.M117.787994 |
Access Rights: | Open Access via Publisher website |
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