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Mannitol is required for asexual sporulation in the wheat pathogen Stagonospora nodorum (glume blotch)

Solomon, Peter; Waters, Ormonde D. C.; Jörgens, Cordula I.; Lowe, Rohan G T; Rechberger, Judith; Trengrove, Robert D.; Oliver, Richard Peter


The physiological role of the mannitol cycle in the wheat pathogen Stagonospora nodorum (glume blotch) has been investigated by reverse genetics and metabolite profiling. A putative mannitol 2-dehydrogenase gene (Mdh1) was cloned by degenerate PCR and disrupted. The resulting mutated mdh1 strains lacked all detectable NADPH-dependent mannitol dehydrogenase activity. The mdh1 strains were unaffected for mannitol production but, surprisingly, were still able to utilize mannitol as a sole carbon...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Biochemical Journal
DOI: 10.1042/BJ20060891


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