DeBono, Aaron J.; Mistry, Sarah J.; Xie, Jinhan; Muthiah, Divya; Phillips, Jackson; Ventura, Sabatino; Callaghan, Richard; Pouton, Colin W.; Capuano, Ben; Scammells, Peter J.
Noscapine, a phthalideisoquinoline alkaloid derived from Papaver somniferum, is a well-known antitussive drug that has a relatively safe in vitro toxicity profile. Noscapine is also known to possess weak anticancer efficacy, and since its discovery, efforts have been made to design derivatives with improved potency. Herein, the synthesis of a series of noscapine analogues, which have been modified in the 6', 9', 1 and 7-positions, is described. In a previous study, replacement of the naturally...[Show more]
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