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Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress

Blackburn, Anneke; Coggan, Marjorie; Shield, Alison; Cappello, Jean; Theodoratos, Angelo; Murray, Tracy; Rooke, Melissa; Larter, Claire; Koina, Mark; Matthaei, Klaus; Board, Philip; Dahlstrom, Jane


Glutathione transferase kappa (GSTK1-1) is a highly conserved, mitochondrial enzyme potentially involved in redox reactions. GSTK1-1-deficient mice were generated to further study the enzyme's biological role. Reduced and total glutathione levels in liver and kidney were unchanged by GSTK1-1 deficiency and NADPH quinone oxidoreductase 1 expression was not elevated indicating that there is no general underlying oxidative stress in Gstk1 / mice. Electron microscopy of liver and kidney showed no...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Laboratory Investigation
DOI: 10.1038/labinvest.2011.107


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