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A Polymer Surfactant Corona Dynamically Replaces Water in Solvent-Free Protein Liquids and Ensures Macromolecular Flexibility and Activity

Gallat, Francois-Xavier; Brogan, Alex P S; Fichou, Yann; McGrath, Nina; Moulin, Martine; Hartlein, Michael; Combet, Jerome; Wuttke, Joachim; Mann, Stephen; Zaccai, Giueppe; Jackson, Colin; Perriman, Adam W; Weik, Martin


The observation of biological activity in solvent-free protein-polymer surfactant hybrids challenges the view of aqueous and nonaqueous solvents being unique promoters of protein dynamics linked to function. Here, we combine elastic incoherent neutron scattering and specific deuterium labeling to separately study protein and polymer motions in solvent-free hybrids. Myoglobin motions within the hybrid are found to closely resemble those of a hydrated protein, and motions of the polymer...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja303894g


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