Enders, Anselm; Bouillet, Philippe; Puthalakath, Hamsa; Xu, Yeukang; Tarlinton, David M.; Strasser, Andreas
During development, the stochastic process assembling the genes encoding antigen receptors invariably generates B and T lymphocytes that can recognize self-antigens. Several mechanisms have evolved to prevent the activation of these cells and the concomitant development of autoimmune disease. One such mechanism is the induction of apoptosis in developing or mature B cells by engagement of the B cell antigen receptor (BCR) in the absence of T cell help. Here we report that B lymphocytes lacking...[Show more]
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