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Ablation of C3 modulates macrophage reactivity in the outer retina during photo-oxidative damage

Jiao, Haihan Helen; Provis, Jan; Natoli, Riccardo; Rutar, Matt


Purpose Dysregulation of the complement cascade contributes to a variety of retinal dystrophies, including age-related macular degeneration (AMD). The central component of complement, C3, is expressed in abundance by macrophages in the outer retina, and its ablation suppresses photoreceptor death in experimental photo-oxidative damage. Whether this also influences macrophage reactivity in this model system, however, is unknown. We investigate the effect of C3 ablation on macrophage activity...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Molecular Vision


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