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Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

Yap, Yanne W.; Rusu, Patrick M.; Chan, Andrea Y.; Fam, Barbara C.; Jungmann, Andreas; Solon-Biet, Samantha M.; Barlow, Christopher K.; Creek, Darren J.; Huang, Cheng; Schittenhelm, Ralf B.; Broer, Stefan


Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by mimicking amino acid (AA) supply from a casein-based diet, we demonstrate that restriction of dietary essential AA (EAA), but not non-EAA, drives the systemic metabolic response to total AA deprivation; independent from dietary carbohydrate supply. Furthermore, systemic deprivation of threonine and tryptophan, independent of total AA...[Show more]

CollectionsANU Research Publications
Date published: 2020-06-09
Type: Journal article
Source: Nature Communications
DOI: 10.1038/s41467-020-16568-z
Access Rights: Open Access


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