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Bacillus cereus: Epidemiology, Virulence Factors, and Host-Pathogen Interactions

Enosi Tuipulotu, Daniel; Mathur, Anukriti; Ngo, Chinh; Man, Si Ming

Description

Bacillus cereus is an important human pathogen, and new findings have expanded our understanding of how this bacterium causes disease. B. cereus Hemolysin BL (HBL) and nonhemolytic enterotoxin (NHE) induce membrane pore formation, leading to activation of the NLRP3 inflammasome, systemic inflammation, and death. Lipopolysaccharide-induced tumor necrosis factor (TNF)-α factor (LITAF) and cell death-inducing P53 target 1 (CDIP1) are bona fide mammalian surface receptors of HBL. These newly...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
URI: http://hdl.handle.net/1885/219768
Source: Trends in Microbiology
DOI: 10.1016/j.tim.2020.09.003
Access Rights: Open Access

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