A Second-Generation Chemoenzymatic Total Synthesis of Platencin
-
Altmetric Citations
Banwell, Martin; Muhammad, Rehmani; Draffan, Alistair; Willis, Anthony
Description
A total synthesis of the potent antibacterial agent platencin is described. The reaction sequence used involves, as starting material, an enantiomerically pure cis-1,2-dihydrocatechol derived from the whole-cell biotransformation of iodobenzene. Simple chemical manipulations of this metabolite provide a triene that engages in a thermally promoted intramolecular Diels–Alder reaction to establish the octahydro-2H-2,4a-ethanonaphthalene core of platencin.
Collections | ANU Research Publications |
---|---|
Date published: | 2015 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/219214 |
Source: | Synlett |
DOI: | 10.1055/s-0035-1560814 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
s-0035-1560814.pdf | 188.13 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator