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Impact of Hydrogen Bonding on the Susceptibility of Peptides to Oxidation

Chan, Bun; Moran, Damian; Easton, Chris; Radom, Leo

Description

The tendency of peptides to be oxidized is intimately connected with their function and even their ability to exist in an oxidative environment. Here we report high-level theoretical studies that show that hydrogen bonding can alter the susceptibility of peptides to oxidation, with complexation to a hydrogen-bond acceptor facilitating oxidation, and vice versa, impacting the feasibility of a diverse range of biological processes. It can even provide an energetically viable mechanistic...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218116
Source: Chemistry - An Asian Journal
DOI: 10.1002/asia.201700492

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