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Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding

Richardson, J; Steele, Gregory A.; Gallant, Esther; Lam, Alexander; Schwartz, Charles E; Board, Philip; Casarotto, Marco; Beard, Nicole; Dulhunty, Angela


Ryanodine receptor (RyR) Ca2+ channels are central to striated muscle function and influence signalling in neurons and other cell types. Beneficially low RyR activity and maximum conductance opening may be stabilised when RyRs bind to FK506 binding proteins (FKBPs) and destabilised by FKBP dissociation, with submaximal opening during RyR hyperactivity associated with myopathies and neurological disorders. However, the correlation with submaximal opening is debated and quantitative evidence is...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Journal of Cell Science
DOI: 10.1242/jcs.204461


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