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Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor

Casarotto, Marco; Cui, Yan Fang; Karunasekara, Yamuna; Harvey, Peta; Norris, Nicole; Board, Philip; Dulhunty, Angela


1. Excitation-contraction coupling in skeletal muscle is dependent on a physical interaction between the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR). 2. A number of peptides derived from the II-III loop region of the DHPR have been shown to be functionally active in stimulating the release of calcium via RyR channels. Their function has been found to correlate with the presence of a basic helical region located at the N-terminus of the II-III loop. 3. The entire recombinant...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1111/j.1440-1681.2006.04501.x


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