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A randomized trial of serological and cellular responses to hepatitis B vaccination in chronic kidney disease

da Silva, Elizabeth; Baker, Alan; AlShekaili, Jalila; Karpe, K.M.; Cook, Matthew


Background Chronic kidney disease (CKD) is associated with an increased risk of hepatitis B infection and impaired seroconversion to hepatitis B vaccine (HBV). Studies examining augmented vaccine schedules to enhance seroconversion have so far been inconclusive. Furthermore, the defects responsible for impaired vaccine immunity in CKD have not yet been identified. Methods We studied serological and cellular responses to HBV in CKD to identify a defect in vaccine-induced cellular responses...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0204477
Access Rights: Open Access


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