Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia.
Canfell, Karen; Banks, Emily; Moa, Aye M; Beral, Valerie
Description
Objective: To determine if the recent rapid fall in use of hormone replacement therapy (HRT) in Australia has been followed by a reduction in breast cancer incidence among women aged 50 years or older, but not among younger women. Design and setting: Analysis of trends in annual prescribing of HRT, using Pharmaceutical Benefits Scheme data, and in annual age-standardised breast cancer incidence rates in Australian women for the period 1996-2003. Results: In Australia, prescribing of HRT...[Show more]
dc.contributor.author | Canfell, Karen | |
---|---|---|
dc.contributor.author | Banks, Emily | |
dc.contributor.author | Moa, Aye M | |
dc.contributor.author | Beral, Valerie | |
dc.date.accessioned | 2015-12-07T22:23:45Z | |
dc.identifier.issn | 0025-729X | |
dc.identifier.uri | http://hdl.handle.net/1885/20849 | |
dc.description.abstract | Objective: To determine if the recent rapid fall in use of hormone replacement therapy (HRT) in Australia has been followed by a reduction in breast cancer incidence among women aged 50 years or older, but not among younger women. Design and setting: Analysis of trends in annual prescribing of HRT, using Pharmaceutical Benefits Scheme data, and in annual age-standardised breast cancer incidence rates in Australian women for the period 1996-2003. Results: In Australia, prescribing of HRT increased from 1996 to 2001, but dropped by 40% from 2001 to 2003. Age-standardised breast cancer incidence rates in women aged ≥ 50 years also increased to 2001 but declined thereafter. The incidence rates in this age group were lower by 6.7% (95% CI, 3.9%-9.3%; P < 0.001) in 2003 compared with 2001, equivalent to 600 (95% CI, 350-830) fewer breast cancers (out of about 9000 incident breast cancers annually for women this age). There was no significant change in breast cancer incidence for women aged < 50 years. Conclusions: While other factors may have contributed to a recent reduction in breast cancer incidence among Australian women aged ≥ 50 years, the available evidence suggests that much of the decrease is due to the recent fall in use of HRT. This is consistent with other evidence that the HRT-associated increase in risk of breast cancer is reversible after ceasing use of HRT. | |
dc.publisher | Australasian Medical Association | |
dc.source | Medical Journal of Australia | |
dc.subject | Keywords: adult; age distribution; article; Australia; breast cancer; cancer incidence; cancer risk; cancer susceptibility; female; hormone substitution; human; major clinical study; prescription; risk reduction; trend study | |
dc.title | Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia. | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 188 | |
dc.date.issued | 2008 | |
local.identifier.absfor | 111706 - Epidemiology | |
local.identifier.ariespublication | u4468094xPUB14 | |
local.type.status | Published Version | |
local.contributor.affiliation | Canfell, Karen, Cancer Counsil NSW | |
local.contributor.affiliation | Banks, Emily, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Moa, Aye M, Cancer Council NSW | |
local.contributor.affiliation | Beral, Valerie, University of Oxford | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 11 | |
local.bibliographicCitation.startpage | 641 | |
local.bibliographicCitation.lastpage | 644 | |
dc.date.updated | 2015-12-07T09:22:15Z | |
local.identifier.scopusID | 2-s2.0-48049103271 | |
local.identifier.thomsonID | 000257774100006 | |
Collections | ANU Research Publications |
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01_Canfell_Decrease_in_breast_cancer_2008.pdf | 212.88 kB | Adobe PDF |
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