Helicobacter heilmannii Colonization Is Associated With High Risk for Gastritis
Date
2019
Authors
Mohammadi, Mahnaz
Abadi, Amin Talebi Bezmin
Rahimi, Farid
Forootan, Mojgan
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier BV
Abstract
Introduction. We aimed to study potential associations between colonization by four
common non-pylori Helicobacter species and gastroduodenal diseases by comparing
samples from patients infected with H. pylori with samples from non-infected subjects.
Materials and Methods. Patients (n 5 190) who were subjected to upper gastrointestinal
endoscopy because of gastroduodenal conditions were enrolled in this cross-sectional
study. Antral biopsy samples were taken from patients in two major hospitals (Mehrad
and Imam-Hossein) in Tehran, Iran, during 2017e2018. DNA was isolated from the biopsy specimens, and PCR amplification was used to identify the Helicobacter species by
using their corresponding specific primer sets.
Results. Out of 120 cases positive for H. pylori, 46 (38%) were patients with gastritis, 23
(19%) with duodenal ulcer, 11 (9%) with gastric cancer, and 40 (33.3%) with gastric ulcer. Overall, 70 (36%) patients were negative for H. pylori. H. pylori cases were uninfected by any of the other tested Helicobacter species. Among the 70 patients without
H. pylori, 34 had gastritis—31 (94%) of these were positive also for H. heilmannii
( p 5 0.001, Odds Ratio: 51.6; 95% Confidence Intervals: 11.8e225.6). We did not find
any patient carrying mixed Helicobacter infections with any non-pylori Helicobacter species in this cohort.
Conclusions. Given our evidence about the possibility of involvement of H. heilmannii in
patients suffering from gastritis and nonexistence of mixed non-pylori Helicobacter infections, bacteriological testing of subjects negative for H. pylori becomes clinically relevant and important.
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Source
Archives of Medical Research
Type
Journal article
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DOI
10.1016/j.arcmed.2019.11.001
Restricted until
2037-12-31