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The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila

Hopkins, Davis; Rane, R.V.; Younus, Faisal; Coppin, C.W.; Pandey, Gunjan; Jackson, Colin; Oakeshott, J.G.


The Drosophila melanogaster enzymes juvenile hormone esterase (DmJHE) and its duplicate, DmJHEdup, present ideal examples for studying the structural changes involved in the neofunctionalization of enzyme duplicates. DmJHE is a hormone esterase with precise regulation and highly specific activity for its substrate, juvenile hormone. DmJHEdup is an odorant degrading esterase (ODE) responsible for processing various kairomones in antennae. Our phylogenetic analysis shows that the JHE lineage...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Insect Biochemistry and Molecular Biology
DOI: 10.1016/j.ibmb.2019.01.001


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