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Synthetic Studies on the Marine-Derived Sesquiterpene (+)-Viridianol: Divergent Behaviour of Two Structurally Related, Ring-Fused Cyclopropanes Under the Same Hydrogenolytic Conditions

Bolte, Benoit; Tang, Fei; Lan, Ping; Willis, Anthony; Banwell, Martin


Hydrogenolytic cleavage of the ring-fused cyclopropane 11 using hydrogen in the presence of platinum oxide afforded the gem-dimethylated cyclohexane 12 in 99 % yield. In contrast, analogous treatment of congener 13 afforded only trace amounts of the targeted and gem-dimethylated sesquiterpene (+)-viridianol (1), the major products of reaction now being the vic-dimethylated compound 14 and the 2-fold ring-cleavage product 15.

CollectionsANU Research Publications
Date published: 2019-01-24
Type: Journal article
Source: Australian Journal of Chemistry
DOI: 10.1071/CH18532


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