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The centrosome protein AKNA regulates neurogenesis via microtubule organization

Ortega, Germán Camargo; Falk, Sven; Johansson, Pia A.; Peyre, Elise; Broix, Loïc; Sahu, Sanjeeb Kumar; Hirst, William; Schlichthaerle, Thomas; Romero, Camino De Juan; Draganova, Kalina; Vinopal, Stanislav


The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors1 that delaminate and settle in the subventricular zone in enlarged brain regions2. The length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination. Here we show...[Show more]

CollectionsANU Research Publications
Date published: 2019-02-20
Type: Journal article
Source: Nature
DOI: 10.1038/s41586-019-0962-4


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