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Molecular mechanisms responsible for programmed cell death-inducing attributes of terpenes from Mesua ferrea stem bark towards human colorectal carcinoma HCT 116 cells

Asif, Muhammad; Al-Mansoub, Majed Ahmed; Khan, Md Shamsuddin Sultan; Yehya, Ashwaq H. S.; Ezzat, Mohammed Oday; Oon, Chern Ein; Atif, Muhammad; Majid, Aman Shah Abdul; Abdul Majid, Amin Malik Shah Bin

Description

The current study explored the in vitro anticancer properties of Mesua ferrea stem bark (SB) extract towards human colon carcinoma HCT116 cells. SB was successively extracted with different solvents using soxhlet apparatus. MTT assay was employed to test toxicity against different cancer and normal cell lines. Active extract (n-Hexane) was fractionated by column chromatography (CC) to get the most active fraction (F-3). Series of in vitro assays were employed to characterize cytotoxic nature of...[Show more]

CollectionsANU Research Publications
Date published: 2017-01-01
Type: Journal article
URI: http://hdl.handle.net/1885/195329
Source: Journal of Applied Biomedicine
DOI: 10.1016/j.jab.2016.10.003
Access Rights: Open Access

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