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Silencing the silencer: strategies to inhibit microRNA activity

Reichel, Marlene; Li, Jun; Millar, Anthony

Description

Plants and animals microRNAs (miRNAs) have been proposed to be key regulators of many fundamental processes. However defining miRNAs function has been problematic due to the paucity of miRNA loss-of-function mutants. This is likely due to their small gene size and redundancy as most miRNA have highly related family members. Consequently, the analysis of miRNA function has been primarily based on predictive bioinformatic or transgenic gain-of-function approaches. However, a number of new...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/19474
Source: Biotechnology Letters
DOI: 10.1007/s10529-011-0590-z

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