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Autophagy generates retrogradely transported organelles: a hypothesis

Kaasinen, Selma; Hendry, Ian; Harvey, L; Reynolds, Anna J

Description

Nerve cells require trophic signals transmitted from the nerve terminal via the axon in order to survive and develop normally. As the axon may be more than a meter long, specialised mechanisms are needed to transmit these signals. This involves the retrograde axonal transport of signalling endosomes containing nerve growth factor (NGF) and other synaptically derived molecules. These are large, double membrane multivesicular bodies containing a mixture of all vesicle types seen in the nerve...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/19249
Source: International Journal of Developmental Neuroscience
DOI: 10.1016/j.ijdevneu.2008.03.011

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