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A Naturally Occurring Novel Allele of Escherichia coli Outer Membrane Protein A Reduces Sensitivity to Bacteriophage

Power, Michelle L.; Ferrari, Belinda; Littlefield-Wyer, Jane; Gordon, David; Slade, Martin; Veal, Duncan


A novel Escherichia coli outer membrane protein A (OmpA) was discovered through a proteomic investigation of cell surface proteins. DNA polymorphisms were localized to regions encoding the protein's surface-exposed loops which are known phage receptor sites. Bacteriophage sensitivity testing indicated an association between bacteriophage resistance and isolates having the novel ompA allele.

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Applied and Environmental Microbiology
DOI: 10.1128/AEM.01040-06
Access Rights: Open Access


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