Comment: Monitoring the pulse of thrombus formation: comment on 'Modeling thrombosis in silico: frontiers, challenges, unresolved problems and milestones' by A.V. Belyaev et al.
Date
2018-11
Authors
Andrews, Robert K
Gardiner, Elizabeth
Journal Title
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Volume Title
Publisher
Elsevier
Abstract
The study of platelet function in vitro under conditions that mimic blood flow remains a challenging area of research, due to the complexity of platelet interactions that occur rapidly and often irreversibly. However, the advent of
increasingly powerful and sensitive microscopy and imaging approaches has enabled many new observations around
platelet molecular events as a thrombus forms. The article by Belyaev and colleagues [1] elegantly reviews the current
state of knowledge in this area, and provides a valuable overview of different ways to computationally analyse and
model platelet adhesion data acquired under experimental conditions simulating blood flow. Interestingly, the impact
of fluid shear stress on platelet biology stretches well beyond simply triggering platelets to adhere and aggregate in a
flowing channel and we will highlight some of the additional aspects that may be clinically relevant and worthwhile
considering in this context [1].
Description
Keywords
Platelets, Thrombosis, Receptor, Pulsatile flow, Shear forces
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Source
Physics of Life Reviews
Type
Journal article
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Restricted until
2037-12-31
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