Winterberg, Markus; Rajendran, Esther; Baumeister, Stefan; Bietz, Sven; Kirk, Kiaran; Lingelbach, Klaus
Human erythrocytes have a low basal permeability to L-glutamate and are not known to have a functional glutamate transporter. Here, treatment of human erythrocytes with arsenite was shown to induce the uptake of L-glutamate and D-aspartate, but not that of D-glutamate or L-alanine. The majority of the arsenite-induced L-glutamate influx was via a high-affinity, Na+-dependent system showing characteristics of members of the "excitatory amino acid transporter" (EAAT) family. Western blots and...[Show more]
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