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Diet-Induced Obesity Impairs Endothelium-Derived Hyperpolarization via Altered Potassium Channel Signaling Mechanisms

Haddock, Rebecca; Grayson, T. Hilton; Morris, Margaret J.; Howitt, Lauren; Chadha, Preet S; Sandow, Shaun L.


BACKGROUND The vascular endothelium plays a critical role in the control of blood flow. Altered endothelium-mediated vasodilator and vasoconstrictor mechanisms underlie key aspects of cardiovascular disease, including those in obesity. Whilst the mechanism of nitric oxide (NO)-mediated vasodilation has been extensively studied in obesity, little is known about the impact of obesity on vasodilation to the endothelium-derived hyperpolarization (EDH) mechanism; which predominates in smaller...[Show more]

CollectionsANU Research Publications
Date published: 2011-01-21
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0016423


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