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Electrical Advantages of Dendritic Spines

Gulledge, Allan T.; Carnevale, Nicholas T.; stuart, greg

Description

Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the absence of spines, the amplitudes and kinetics of excitatory postsynaptic potentials (EPSPs) at the site of synaptic input are highly variable and depend on dendritic location. We hypothesized that dendritic spines standardize the local geometry at the site of synaptic input, thereby reducing location-dependent variability of local EPSP properties. We tested this hypothesis using computational...[Show more]

CollectionsANU Research Publications
Date published: 2012-04-20
Type: Journal article
URI: http://hdl.handle.net/1885/16867
Source: PLoS ONE
DOI: 10.1371/journal.pone.0036007

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