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TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells

McCoy, James M.; Whitehead, Lachlan; van Dooren, Giel G.; Tonkin, Christopher J.


The phylum Apicomplexa comprises a group of obligate intracellular parasites of broad medical and agricultural significance, including Toxoplasma gondii and the malaria-causing Plasmodium spp. Key to their parasitic lifestyle is the need to egress from an infected cell, actively move through tissue, and reinvade another cell, thus perpetuating infection. Ca(2+)-mediated signaling events modulate key steps required for host cell egress, invasion and motility, including secretion of microneme...[Show more]

CollectionsANU Research Publications
Date published: 2012-12-04
Type: Journal article
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1003066


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