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Independent Evolution of Transcriptional Inactivation on Sex Chromosomes in Birds and Mammals

Livernois, Alexandra M.; Waters, Shafagh A.; Deakin, Janine E.; Marshall Graves, Jennifer A.; Waters, Paul D.


X chromosome inactivation in eutherian mammals has been thought to be tightly controlled, as expected from a mechanism that compensates for the different dosage of X-borne genes in XX females and XY males. However, many X genes escape inactivation in humans, inactivation of the X in marsupials is partial, and the unrelated sex chromosomes of monotreme mammals have incomplete and gene-specific inactivation of X-linked genes. The bird ZW sex chromosome system represents a third independently...[Show more]

CollectionsANU Research Publications
Date published: 2013-07-18
Type: Journal article
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.1003635


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