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Analysis of Epigenetic Factors in Mouse Embryonic Neural Stem Cells Exposed to Hyperglycemia

Shyamasundar, Sukanya; Jadhav, Shweta P.; Bay, Boon Huat; Tay, Samuel Sam Wah; Kumar, S. Dinesh; Rangasamy, Danny; Dheen, S. Thameem


BACKGROUND Maternal diabetes alters gene expression leading to neural tube defects (NTDs) in the developing brain. The mechanistic pathways that deregulate the gene expression remain unknown. It is hypothesized that exposure of neural stem cells (NSCs) to high glucose/hyperglycemia results in activation of epigenetic mechanisms which alter gene expression and cell fate during brain development. METHODS AND FINDINGS NSCs were isolated from normal pregnancy and streptozotocin induced-diabetic...[Show more]

CollectionsANU Research Publications
Date published: 2013-06-11
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0065945


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