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MHC Class II–Alpha Chain Knockout Mice Support Increased Viral Replication That Is Independent of Their Lack of MHC Class II Cell Surface Expression and Associated Immune Function Deficiencies

Alsharifi, Mohammed; Koskinen, Aulikki; Wijesundara, Danushka K.; Bettadapura, Jayaram; Müllbacher, Arno


MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function of CD4 T cells. Various MHC-II knockout mice have been generated including MHC-IIAα(-/-) (I-Aα(-/-)), MHC-IIAβ(-/-) (I-β(-/-)) and the double knockout (I-Aαxβ(-/-)). Here we report a very striking observation, namely that alphaviruses including the...[Show more]

CollectionsANU Research Publications
Date published: 2013-06-28
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0068458


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